Red Mesa is presumably a city or town near Night Vale. Despite this, it is unclear where the town is. Not much is known about the town, but it is assumed they are not nearly as hated as the people in Desert Bluffs.
- Glow Cloud: a special announcement about the escape of fugitive Hiram McDaniels notes that he had been spotted flying and shrieking over Red Mesa.
- Homecoming. it is revealed that their high school football team is called the Red Mesa High School Ant Carpenters; they played in the 2014 homecoming game against the Night Vale Scorpions, and, according to Cecil, were dreadful.
- The 12:37: the train that the episode is centered around is supposedly going to Red Mesa, but at the end the destination is left unknown.
- Fall Football Preview: it is revealed that their footbal team, Red Mesa Ant Carpenters, is a district champion.