First mentioned in the episode Yellow Helicopters, the Night Vale Medical Board is a public service that sporadically sends messages to be read on air. These can vary widely, ranging from the results of new medical studies to PSAs about dermatological growths.

It is believed that at least part of the Night Vale Medical Board is comprised of snakes, because--when asked by a reporter about organ donations--one board member "was quoted as saying something that resembled a hiss, and then quickly biting the reporter's ankle."